Hemostasis Reference Laboratory

D-dimer

• Transaction Code: 3210-27
• CPT Code (Suggested): 85378

D-dimer is a specific degradation product of factor XIII-crosslinked fibrin. A monoclonal antibody that recognizes cross-linked D-dimer fragments is used in a semi-quantitative latex agglutination assay. The D-dimer assay is more specific for fibrin degradation than the FDP assay, which detects degradation products of both soluble fibrinogen as well as crosslinked fibrin. D-dimer levels can be elevated in disseminated intravascular coagulation (DIC), liver disease, or venous thromboembolic disease. The presence of rheumatoid factor can result in a false positive D-dimer.

• Sample Required: 0.5 ml frozen plasma x4 or (2) 3.2% sodium citrated tubes, 5 ml each.
• See Sample Requirements when ordered with other tests.
• Normal Range: < 0.5 mg/µl
• Analytic Time: Within 5 working days