Platelet Immunology Laboratory

Platelet Drug Antibody Test (Drug-Related ITP)

• Test Code: 3650-00
• CPT Codes: 86022 (x4), 86023 (x8), 83912

Many drugs have been reported to be associated with severe thrombocytopenia. Quinine, quinidine, and heparin are the drugs most commonly associated with thrombocytopenia. An increased binding of antibody to the patient's platelets or random donor platelets in the presence of the offending drug is suggestive of drug-induced thrombocytopenia.

Accurate patient information is important to ensure that the correct drug is sent to the Plaetelet Immunology Laboratory for testing with the patient's plasma/platelets. It is imperative to note whether or not the patient is still on the suspected drug. A positive test result proVides relevant information, while a negative test result does not exclude a drug related antibody. A false negative test result may occur for a variety of reasons (the concentration of the drug added to the test was not appropriate; it may be a metabolite of the drug rather than the native drug that has caused the thrombocytopenia, etc.).

• Tests Performed: Flow cytometry, Tests are performed with and without the drug added to the assay system
• Test Types: Direct and Indirect
• Sample Required: Call the Platelet Immunology Laboratory at 206-292-6543 for sample and drug requirements
• Analytic Time: 1 Day
• Send whole blood, room temperature
• Refer to Ordering Information page for submission and transporting requirements