One recently funded project is entitled “Race-Based Mechanisms of Factor VIII Immunogenicity in Hemophilia”. T-cell and B-cell responses to FVIII are being investigated using blood samples from a large number of hemophilia A blood donors. The methods described above are being applied to answer the question of why immune responses develop in hemophilia A patients with black African ancestry much more frequently than in Caucasian patients with similar disease-causing mutations. Identifying reasons for this discrepancy will hopefully lead, eventually, to more effective treatments for hemophilia A patients.
| We are actively recruiting scientists to help with this project, which will begin in November 2009. Please contact Dr. Pratt if you would like to explore opportunities to work with us. |
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Left to Right: Devi Gunasekera, Rebecca Lefavor, Kathleen Pratt, Colette Norby-Slycord, Ken Lewis, Ruth Ettinger, Amjad Hussain, and Phuong-cac Nguyen. |
